2. Test datasets

We provide seven test datasets generated from using Illumina HumanMethylation450 (450K), MethylationEPIC v1.0 (850K), MethylationEPIC v2.0 and RRBS.

2.1. Test data 1

	Test data 1
Source	Mayo Clinic
Tissue	Blood
Platform	MethylationEPIC v1.0 (850K)
# of CpG	865859
# of samples	20
Age range (year)	(49, 82)
Data file	Test1_blood_N20_EPICv1_beta.tsv.gz
MD5 (Data file)	528a5896bcaae4a77757c35c7abcd507
Meta info file	Test1_blood_N20_EPICv1_info.tsv

2.2. Test data 2

	Test data 2
Source	GEO (GSE56105)
Tissue	Blood
Platform	HumanMethylation450 (450K)
# of CpG	478313
# of samples	80
Age range (year)	(10, 60)
Data file	Test2_blood_N80_450K_beta.tsv.gz
MD5 (Data file)	95e5f8ca6ab10c015644a0ff03b4b7be
Meta info file	Test2_blood_N80_450K_info.tsv

2.3. Test data 3

	Test data 3
Source	Mayo Clinic
Tissue	Liver
Platform	HumanMethylation450 (450K)
# of CpG	485512
# of samples	32
Age range (year)	(2, 81)
Data file	Test3_liver_N32_450K_beta.tsv.gz
MD5 (Data file)	a868457bd3d50aadeb5f34d50ef82dc6
Meta info file	Test3_liver_N32_450K_info.tsv

2.4. Test data 4

	Test data 4
Source	GEO (GSE229715)
Tissue	Brain
Platform	MethylationEPIC v2.0
# of CpG	853304
# of samples	16
Age range (year)	(0.4, 77)
Data file	Test4_brain_N16_EPICv2_beta.tsv.gz
MD5 (Data file)	ec566e0cf5b5dd48ed4797e132b326dd
Meta info file	Test4_brain_N16_EPICv2_info.tsv

2.5. Test data 5

	Test data 5
Source	GEO (GSE62924)
Tissue	Cord Blood
Platform	450K
# of CpG	484667
# of samples	38
Age range (week)	(34, 41)
Data file	Test5_CordBlood_N38_450K_beta.tsv.gz
MD5 (Data file)	0cf912f55a43dbbadaab8fd2371811be
Meta info file	Test5_CordBlood_N38_450K_info.tsv

2.6. Test data 6

	Test data 6
Source	GEO (GSE44667)
Tissue	Placental chorionic villus
Platform	450K
# of CpG	430685
# of samples	40
Age range (week)	(24, 38)
Data file	Test6_Placentas_N40_450K_beta.tsv.gz
MD5 (Data file)	8cb8074657a8b8d1b11e96bd1cce4165
Meta info file	Test6_Placentas_N40_450K_info.tsv

2.7. Test data 7

	Test data 7
Source	GEO (GSE121141)
Tissue	Mouse multiple tissue.
Platform	RRBS
# of CpG	994
# of samples	81
Age range (days)	(180, 900)
Data file	Test7_mouse_N81_RRBS_beta.tsv
MD5 (Data file)	98456e98a2ffddb9e78b048e048279fe
Meta info file	Test7_mouse_N81_RRBS_info.tsv